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Medical Root Words List With Meanings (By Body System)

Medical student in a white coat studying at a library desk, with the title Medical Root Words: list with meanings, by body system.

A medical root word (also called a word root) is the core of a medical term and carries its main meaning, usually a body part: cardi means heart, hem or hemat means blood and my or muscul means muscle. Add a combining vowel, usually o, and you get a combining form such as cardi/o, which links the root to suffixes and other roots to build terms like cardiology, the study of the heart.

Below are the most useful root words and combining forms by body system, plus colors and general words, each with its meaning and a real example term. You will also find Greek and Latin pairs, look-alike roots, worked examples and a short quiz. For the beginnings and endings of terms, see our list of medical prefixes and suffixes with meanings and examples.

In this guide:

Word Roots, Combining Forms and Combining Vowels

A word root is the foundation of a medical term. Most roots name a body part (gastr, stomach), but some name a substance (glyc, sugar), a color (erythr, red) or a quality (scler, hard). Most medical terms contain at least one root, and many contain two or more.

A combining vowel, usually o, links a root to another word part and makes the term easier to say. A root plus its combining vowel is a combining form, written with a slash: gastr/o. The vowel is occasionally i or e, as in pelv/i (pelvis) and chol/e (bile). Three rules cover most terms:

  1. Keep the vowel before a suffix that starts with a consonant: gastr/o + -scopy = gastroscopy.
  2. Drop the vowel before a suffix that starts with a vowel: gastr/o + -itis = gastritis, not "gastroitis."
  3. Keep the vowel between two roots, even when the second root starts with a vowel: gastr/o + enter/o + -logy = gastroenterology.

A few established terms break these rules, and some roots have more than one form with the same meaning, such as hem/o and hemat/o (blood) or ten/o, tend/o and tendin/o (tendon). When in doubt, check the spelling in a medical dictionary.

Cardiovascular System Root Words

Combining form Meaning Example term (meaning)
cardi/o heart Cardiomegaly: an enlarged heart
angi/o vessel (usually a blood vessel) Angioplasty: a procedure to widen a narrowed or blocked blood vessel
vas/o vessel; also duct (the vas deferens) Vasoconstriction: narrowing of blood vessels
arteri/o artery Arteriosclerosis: hardening of the arteries
ather/o fatty plaque Atherosclerosis: hardening and narrowing of the arteries caused by a buildup of fatty plaque
phleb/o vein Phlebitis: inflammation of a vein
ven/o vein Intravenous: within a vein
aort/o aorta Aortic stenosis: narrowing of the aortic valve opening
atri/o atrium (upper chamber of the heart) Atrial fibrillation: an irregular, often fast heart rhythm that starts in the atria
ventricul/o ventricle (lower chamber of the heart; also a fluid-filled cavity in the brain) Ventricular tachycardia: a fast heart rhythm that starts in the ventricles
sphygm/o pulse Sphygmomanometer: the device used to measure blood pressure

Blood and Immune System Root Words

The root words for blood are hem/o and hemat/o. Don't confuse them with the prefix hemi-, which means half.

Combining form Meaning Example term (meaning)
hem/o, hemat/o blood Hematoma: a collection of blood outside the blood vessels
thromb/o clot Thrombosis: formation of a blood clot inside a blood vessel
coagul/o clotting Anticoagulant: a medicine that slows blood clotting
myel/o bone marrow; also spinal cord Myelosuppression: reduced bone marrow activity, so fewer blood cells are made
phag/o eat, swallow Phagocyte: a cell that engulfs and destroys microorganisms and cell debris
immun/o immune, protection Immunology: the study of the immune system
lymph/o lymph Lymphedema: swelling caused by a buildup of lymph fluid
lymphaden/o lymph node Lymphadenopathy: disease of the lymph nodes, most often meaning swollen nodes
splen/o spleen Splenomegaly: an enlarged spleen

Respiratory System Root Words

Combining form Meaning Example term (meaning)
pneum/o, pneumon/o lung; air Pneumonia: an infection of one or both lungs that fills the air sacs with fluid or pus. Pneumothorax: air in the space around a lung, which can make it collapse
pulmon/o lung Pulmonology: the specialty that diagnoses and treats lung diseases
bronch/o, bronchi/o bronchus (large airway) Bronchitis: inflammation of the bronchial tubes
trache/o trachea (windpipe) Tracheostomy: a surgical opening into the windpipe
laryng/o larynx (voice box) Laryngitis: inflammation of the voice box, often causing hoarseness
pharyng/o pharynx (throat) Pharyngitis: inflammation of the throat
rhin/o nose Rhinitis: inflammation of the lining of the nose
pleur/o pleura (membrane around the lungs) Pleurisy: inflammation of the pleura
spir/o breathing Spirometry: a breathing test that measures how much air you can breathe out and how fast you can breathe it out
ox/o, ox/i oxygen Hypoxemia: a low level of oxygen in the blood
thorac/o chest Thoracotomy: a surgical incision into the chest wall

Digestive System Root Words

Combining form Meaning Example term (meaning)
or/o mouth Oral: pertaining to the mouth
stomat/o mouth Stomatitis: inflammation of the lining of the mouth
gloss/o tongue Glossitis: inflammation of the tongue
lingu/o tongue Sublingual: under the tongue
esophag/o esophagus Esophagitis: inflammation of the esophagus
gastr/o stomach Gastritis: inflammation of the stomach lining
enter/o intestine (usually the small intestine) Gastroenteritis: inflammation of the stomach and intestines
col/o, colon/o colon (large intestine) Colitis: inflammation of the colon
proct/o anus and rectum Proctoscopy: examination of the anus and rectum with a scope
hepat/o liver Hepatitis: inflammation of the liver
chol/e bile, gall Cholelithiasis: the presence of gallstones
cholecyst/o gallbladder Cholecystitis: inflammation of the gallbladder
pancreat/o pancreas Pancreatitis: inflammation of the pancreas
lapar/o abdomen, abdominal wall Laparoscopy: examination of the inside of the abdomen with a thin, lighted scope inserted through a small incision

Urinary System Root Words

Watch the spelling: the ureters carry urine from the kidneys to the bladder, and the urethra carries it out of the body.

Combining form Meaning Example term (meaning)
nephr/o kidney Nephrolithiasis: the presence of stones in the kidney
ren/o kidney Renal: pertaining to the kidney
pyel/o renal pelvis (the collecting area in the center of the kidney) Pyelonephritis: inflammation of the renal pelvis and kidney, usually from a bacterial infection
glomerul/o glomerulus (a tiny cluster of capillaries that filters blood) Glomerulonephritis: inflammation of the glomeruli
ur/o, urin/o urine; urinary tract Urinalysis: a laboratory test of a urine sample
ureter/o ureter Ureteroscopy: examination of the ureter with a thin scope
cyst/o urinary bladder; also sac or cyst Cystitis: inflammation of the bladder, usually from infection
vesic/o urinary bladder Vesicoureteral reflux: backward flow of urine from the bladder into the ureters
urethr/o urethra Urethritis: inflammation of the urethra

Reproductive System Root Words

Combining form Meaning Example term (meaning)
hyster/o, uter/o uterus Hysterectomy: removal of the uterus
oophor/o, ovari/o ovary Oophorectomy: removal of one or both ovaries
salping/o fallopian (uterine) tube; also the eustachian (auditory) tube Salpingectomy: removal of a fallopian tube
colp/o, vagin/o vagina Colposcopy: examination of the vagina and cervix with a lighted magnifying instrument
cervic/o cervix (the neck of the uterus); also neck Cervical: pertaining to the cervix, or to the neck
mamm/o, mast/o breast Mammogram: an X-ray image of the breast. Mastectomy: removal of a breast
men/o menstruation Amenorrhea: absence of menstrual periods
gynec/o woman, female Gynecology: the specialty that cares for the female reproductive system
orchi/o, orchid/o, test/o testis (testicle) Orchitis: inflammation of a testicle
prostat/o prostate gland Prostatitis: inflammation of the prostate (note the spelling: prostate, not "prostrate")
vas/o vas deferens; also vessel Vasectomy: cutting or blocking the vas deferens for permanent birth control

Musculoskeletal System Root Words

The root words for muscle are my/o (Greek) and muscul/o (Latin). Both come from words for "mouse," because the shape and movement of some muscles were thought to resemble a mouse.

Combining form Meaning Example term (meaning)
my/o muscle Myalgia: muscle pain. Myocardium: the heart muscle
muscul/o muscle Musculoskeletal: pertaining to the muscles and skeleton
oste/o bone Osteoporosis: a disease that thins and weakens bones so they break more easily
arthr/o joint Arthritis: inflammation of a joint
chondr/o cartilage Costochondritis: inflammation of the cartilage that joins the ribs to the breastbone
ten/o, tend/o, tendin/o tendon Tendinitis (also spelled tendonitis): inflammation of a tendon
cost/o rib Intercostal: between the ribs
crani/o skull Craniotomy: surgical opening of the skull
spondyl/o, vertebr/o vertebra (bone of the spine) Spondylitis: inflammation of the vertebrae

Nervous System Root Words

Combining form Meaning Example term (meaning)
neur/o nerve Neuralgia: pain along the course of a nerve
encephal/o brain Encephalitis: inflammation of the brain
cerebr/o cerebrum (the largest part of the brain) Cerebrovascular: pertaining to the blood vessels of the brain, as in cerebrovascular accident (stroke)
mening/o meninges (membranes covering the brain and spinal cord) Meningitis: inflammation of the meninges
myel/o spinal cord; also bone marrow Myelomeningocele: a birth defect in which the spinal cord and meninges push out through an opening in the spine (the most serious type of spina bifida)
radicul/o nerve root Radiculopathy: irritation of or damage to a spinal nerve root, which can cause pain, numbness or weakness
gli/o glue; glial (supporting) cells of the nervous system Glioma: a tumor that starts in glial cells
esthesi/o sensation, feeling Anesthesia: loss of sensation

Integumentary System (Skin) Root Words

Combining form Meaning Example term (meaning)
derm/o, dermat/o skin Dermatitis: inflammation of the skin
cutane/o skin Subcutaneous: beneath the skin
kerat/o hard, horny tissue (keratin); also cornea Actinic keratosis: a rough, scaly skin patch caused by years of sun exposure that can sometimes turn into skin cancer
onych/o, ungu/o nail Onychomycosis: a fungal infection of a nail
trich/o, pil/o hair Trichotillomania: a disorder of repeatedly pulling out one's own hair
hidr/o sweat Hyperhidrosis: excessive sweating
seb/o sebum (skin oil) Sebaceous gland: an oil-producing gland in the skin

Endocrine System Root Words

For the pancreas (pancreat/o), see the digestive table. Kal/i and natr/o come from the Latin names kalium and natrium, which is why potassium and sodium have the chemical symbols K and Na.

Combining form Meaning Example term (meaning)
aden/o gland Adenoma: a noncancerous tumor that starts in glandular tissue
crin/o secrete Endocrinology: the study and treatment of hormone-producing glands and their disorders
thyr/o, thyroid/o thyroid gland Hyperthyroidism: an overactive thyroid gland
adren/o, adrenal/o adrenal gland Adrenalectomy: removal of an adrenal gland
pituitar/o pituitary gland Hypopituitarism: an underactive pituitary gland
gonad/o sex glands (ovaries or testes) Hypogonadism: a condition in which the sex glands make little or no sex hormones
glyc/o, gluc/o sugar, glucose Hyperglycemia: high blood sugar
kal/i potassium Hyperkalemia: a high level of potassium in the blood
natr/o sodium Hyponatremia: a low level of sodium in the blood
acr/o extremities; also height or top (as in acrophobia, fear of heights) Acromegaly: enlargement of the hands, feet and face caused by too much growth hormone in adulthood

Eye and Ear Root Words

Eye

Combining form Meaning Example term (meaning)
ophthalm/o eye Ophthalmologist: a physician who specializes in eye and vision care, including eye surgery
ocul/o eye Intraocular: within the eye, as in intraocular pressure
opt/o, optic/o eye, vision Optic nerve: the nerve that carries visual signals from the eye to the brain
blephar/o eyelid Blepharitis: inflammation of the eyelids
kerat/o cornea; also hard, horny tissue Keratitis: inflammation of the cornea
retin/o retina Retinopathy: disease of the retina, as in diabetic retinopathy
scler/o sclera (the white of the eye); also hard Scleritis: inflammation of the sclera
conjunctiv/o conjunctiva Conjunctivitis: inflammation of the conjunctiva (pink eye)
lacrim/o, dacry/o tears, tear duct Lacrimal gland: the gland that produces tears

Ear

Combining form Meaning Example term (meaning)
ot/o ear Otitis media: inflammation of the middle ear, often from infection
aur/o, aur/i ear Aural: pertaining to the ear
audi/o hearing Audiometry: a test that measures hearing
myring/o eardrum Myringotomy: a small incision in the eardrum, often to drain fluid or place ear tubes
tympan/o eardrum; also middle ear Tympanic membrane: the eardrum

Root Words for Colors

Combining form Meaning Example term (meaning)
erythr/o red Erythrocyte: a red blood cell
leuk/o white Leukocyte: a white blood cell
melan/o black, dark Melanoma: a cancer that begins in melanocytes, the cells that make the pigment melanin
cyan/o blue Cyanosis: a bluish color of the skin or lips, usually caused by low oxygen in the blood
xanth/o yellow Xanthoma: a yellowish deposit of fat under the skin
cirrh/o tawny yellow, orange-yellow Cirrhosis: severe scarring of the liver, named for the tawny color of the diseased organ
eosin/o rosy, red Eosinophil: a white blood cell whose granules stain red with the dye eosin
poli/o gray Poliomyelitis (polio): a viral disease named for the inflammation it can cause in the gray matter of the spinal cord

General Root Words: Cells, Tissue, Disease, Water and More

These roots appear in every body system. The root word for water is hydr/o; its Latin counterpart, aque/o, is less common. The root for fire is pyr/o, which also means fever, and the root for light is phot/o.

Combining form Meaning Example term (meaning)
cyt/o cell Cytology: the study of cells
hist/o tissue Histology: the study of tissues
path/o disease Pathology: the study of disease
hydr/o water, fluid Dehydration: a condition in which the body loses more water and fluids than it takes in
aque/o water Aqueous humor: the watery fluid in the front part of the eye
lip/o, adip/o fat Lipoma: a noncancerous fatty lump. Adipose tissue: body fat
carcin/o cancer Carcinogen: a substance that can cause cancer
onc/o tumor Oncology: the specialty that diagnoses and treats cancer
sarc/o flesh, connective tissue Sarcoma: a cancer that starts in bone or in soft tissues such as muscle, fat or cartilage
necr/o death Necrosis: death of cells or tissue
fibr/o fiber Fibrosis: thickening and scarring of tissue
lith/o stone Lithotripsy: breaking up stones, for example with shock waves
myc/o fungus Mycosis: a fungal infection
therm/o heat Hypothermia: an abnormally low body temperature
pyr/o, pyret/o fever (pyr/o also means fire) Antipyretic: a medicine that reduces fever
phot/o light Photophobia: abnormal sensitivity to light
iatr/o physician, medical treatment Iatrogenic: caused by medical treatment
xer/o dry Xerostomia: dry mouth

Greek and Latin Pairs That Mean the Same Thing

Medical language borrows from both Greek and Latin, so many body parts have two combining forms. As a loose pattern, Greek forms often name diseases, procedures and specialties (nephritis, nephrology), while Latin forms often describe anatomy (renal artery). There are plenty of exceptions, such as mammography, so learn both.

Meaning Greek form (example) Latin form (example)
kidney nephr/o (nephrectomy) ren/o (renal)
skin derm/o, dermat/o (dermatology) cutane/o (subcutaneous)
eye ophthalm/o (ophthalmology) ocul/o (ocular)
muscle my/o (myalgia) muscul/o (muscular)
bone oste/o (osteoporosis) oss/e, oss/i (osseous)
vein phleb/o (phlebitis) ven/o (intravenous)
lung pneum/o, pneumon/o (pneumonia) pulmon/o (pulmonary)
mouth stomat/o (stomatitis) or/o (oral)
tongue gloss/o (glossitis) lingu/o (sublingual)
nose rhin/o (rhinoplasty) nas/o (nasal)
breast mast/o (mastectomy) mamm/o (mammogram)
uterus hyster/o (hysterectomy) uter/o (uterine)
ovary oophor/o (oophorectomy) ovari/o (ovarian)
vagina colp/o (colposcopy) vagin/o (vaginitis)
urinary bladder cyst/o (cystitis) vesic/o (vesicoureteral)
testis orchi/o (orchitis) test/o (testicular)
joint arthr/o (arthritis) articul/o (articular)
vertebra spondyl/o (spondylitis) vertebr/o (vertebral)
tears dacry/o (dacryocystitis) lacrim/o (lacrimal)
ear ot/o (otitis) aur/o, aur/i (aural)
water hydr/o (hydrocephalus) aque/o (aqueous)

For blood, hem/o and hemat/o are Greek; the Latin root sanguin- appears in only a few terms, such as sanguineous (bloody) wound drainage.

Look-Alike Roots and Roots With Two Meanings

  • my/o, myel/o and myc/o: muscle (myalgia), spinal cord or bone marrow (myelomeningocele, myelosuppression) and fungus (mycosis).
  • hydr/o and hidr/o: water (hydrocephalus) and sweat (hyperhidrosis).
  • hem/o, hemat/o and hemi-: blood (hemorrhage, hematuria) and half (hemiplegia).
  • arthr/o and arteri/o: joint (arthritis) and artery (arteriosclerosis).
  • ile/o and ili/o: the ileum, the last part of the small intestine (ileostomy), and the ilium, the upper part of the hip bone (iliac crest).

Some roots also have two meanings, and the rest of the term or the context tells you which one is meant: acr/o (extremities or height), myel/o (spinal cord or bone marrow), cervic/o (cervix or neck), salping/o (fallopian tube or eustachian tube), kerat/o (cornea or horny tissue), scler/o (sclera or hard), vas/o (vessel or the vas deferens) and cyst/o (urinary bladder or any sac).

How to Break Down a Medical Term

Use the same four steps for any unfamiliar term:

  1. Split it into parts: the suffix at the end, any prefix at the beginning and the root or roots in between.
  2. Define the suffix first.
  3. Define the prefix, if there is one, then the roots in order.
  4. Put the meanings together, then confirm the definition in a medical dictionary or your textbook.

Worked Examples

  • Hepatosplenomegaly = hepat/o (liver) + splen/o (spleen) + -megaly (enlargement): enlargement of the liver and spleen.
  • Cholecystectomy = chol/e (bile) + cyst (bladder, sac) + -ectomy (surgical removal): removal of the "bile bladder," better known as the gallbladder. Note the combining vowel e.
  • Electroencephalogram = electr/o (electricity) + encephal/o (brain) + -gram (record): a recording of the brain's electrical activity (EEG).

Literal meanings are a starting point, not the full definition. Hydrocephalus literally means "water head," but it is an abnormal buildup of cerebrospinal fluid in the ventricles of the brain.

For more practice, MedlinePlus, from the U.S. National Library of Medicine, offers a free Understanding Medical Words tutorial and a list of word parts and what they mean.

Quick Quiz: Medical Root Words

1. What does the combining form hemat/o mean?
a) half
b) blood
c) liver
d) vein

2. Which combining form means muscle?
a) myel/o
b) my/o
c) myc/o
d) mening/o

3. Which term contains the combining form for water?
a) hyperhidrosis
b) hydrocephalus
c) hysterectomy
d) hematoma

4. Nephr/o and ren/o both refer to which organ?
a) liver
b) kidney
c) bladder
d) lung

5. Which combining form means eyelid?
a) blephar/o
b) kerat/o
c) ocul/o
d) ot/o

6. Which term means surgical removal of the uterus?
a) hysterectomy
b) oophorectomy
c) salpingectomy
d) mastectomy

7. Which tube carries urine from a kidney to the urinary bladder?
a) urethra
b) ureter
c) bronchus
d) fallopian tube

8. Which combining form means disease?
a) path/o
b) hist/o
c) cyt/o
d) phag/o

Answers

  1. b) blood. Hem/o and hemat/o both mean blood, as in hematoma. The prefix hemi- means half, and hepat/o means liver.
  2. b) my/o, as in myalgia. Myel/o means spinal cord or bone marrow, myc/o means fungus and mening/o refers to the meninges.
  3. b) hydrocephalus (hydr/o = water). Hyperhidrosis contains hidr/o (sweat), hysterectomy contains hyster/o (uterus) and hematoma contains hemat/o (blood).
  4. b) kidney. Nephr/o is Greek and ren/o is Latin, as in nephrology and renal.
  5. a) blephar/o, as in blepharitis. Kerat/o refers to the cornea (or hard, horny tissue), ocul/o to the eye and ot/o to the ear.
  6. a) hysterectomy (hyster/o = uterus). Oophorectomy removes an ovary, salpingectomy a fallopian tube and mastectomy a breast.
  7. b) ureter. The urethra carries urine from the bladder out of the body.
  8. a) path/o, as in pathology. Hist/o means tissue, cyt/o means cell and phag/o means eat or swallow.

For a longer test, try our free 50-question medical terminology quiz with answers.

Want more practice? Our Medical Terminology Workbook is an exercise-only companion with matching columns, fill-in-the-blank questions, multiple-choice questions, true or false and picture labeling.

Frequently Asked Questions

What is a root word in medical terminology?

A root word, or word root, is the part of a medical term that carries its core meaning, usually a body part. In gastritis, the root gastr means stomach and the suffix -itis means inflammation.

What is the difference between a root word and a combining form?

A combining form is a root word plus a combining vowel, usually o, written with a slash, such as cardi/o. The vowel lets the root join a suffix that starts with a consonant or another root, as in cardiology and cardiomyopathy.

What is the root word for blood?

Hem/o and hemat/o both mean blood, as in hemoglobin and hematology. The suffix -emia means a blood condition, as in anemia.

What is the root word for muscle?

My/o and muscul/o both mean muscle, as in myalgia (muscle pain), myocardium (heart muscle) and musculoskeletal. Don't confuse my/o with myel/o, which means spinal cord or bone marrow.

What is the root word for water?

Hydr/o means water or fluid, as in dehydration and hydrocephalus. The Latin form aque/o appears in aqueous humor. Watch out for hidr/o, which means sweat, as in hyperhidrosis.

What is the best way to learn medical root words?

Learn them by body system with their Greek and Latin pairs, test yourself with flashcards over several days instead of rereading, and break down every new term you meet. For more techniques, see 10 Strategies to Memorize Medical Terminology.

Keep Going

Root words carry the core meaning of most medical terms, so every one you learn makes the next term easier to decode. To keep building your vocabulary, see our Medical Terminology textbook, written by doctors, with more than 100,000 copies sold, and the companion Medical Terminology Workbook for self-testing, or take our online Medical Terminology Course. You can see all our books on our Textbooks page.